VERIGRATE HEALTH · NEUROMODULATION

ONE TREATMENT DAY
DIRECT PHYSICIAN OVERSIGHT
PRIVATE PAY
DALLAS + SELECT PRIVATE LOCATIONS
THE VERIGRATE MODEL
01
CLARIFY
02
RECONSIDER
03
TREAT
04
CONTINUE
THE TREATMENT DAY
01
ARRIVE
02
CALIBRATE
03
TREAT
04
BETWEEN SESSIONS
05
COMPLETE
CONVENTIONAL TMS
ONE-DAY TMS
No efficacy equivalence is claimed between schedules.
THE EVIDENCE
Promising findings. Important limitations.
EMERGING SINGLE-DAY EVIDENCE
A 2025 retrospective, naturalistic, open-label case series reported outcomes in 32 adults with unipolar major depression who underwent an optimized single-day TMS regimen. The published treatment course consisted of 20 intermittent theta-burst stimulation (iTBS) sessions delivered approximately every 30 minutes over about 9.5 hours, together with pharmacologic augmentation.
CHARACTERISTICS OF THE PUBLISHED CASE SERIES — NOT A VERIGRATE TREATMENT PROMISE
32
ADULTS
20
TMS SESSIONS
9.5 hours
APPROXIMATE TREATMENT DAY
26 weeks
LONGEST REPORTED FOLLOW-UP
Reported outcomes at six weeks
On the clinician-rated HDRS-17 depression scale, the case series reported:
87.5%
RESPONSE · HDRS-17
71.9%
REMISSION · HDRS-17
Response was defined as at least 50% improvement. Remission was defined according to the study’s prespecified HDRS-17 threshold.
These percentages describe this uncontrolled case series and should not be interpreted as expected outcomes for an individual patient or as results Verigrate will reproduce.
TIME COURSE
In this case series, symptom improvement continued over the weeks following the treatment day rather than occurring primarily during the treatment itself. Average improvement generally approached a plateau around weeks 4–6.
A one-day treatment schedule does not necessarily mean a one-day clinical response.
What happened over longer follow-up?
At 12 weeks, the reported HDRS-17 response and remission rates remained 84.4% and 71.2%, respectively, using the original 32-patient sample as the denominator.
At approximately 26 weeks, 16 of the original 32 patients—50%—were classified as having sustained remission on both HDRS-17 and BDI-II.
By 26 weeks, some patients had relapsed or received retreatment, and some were lost to follow-up. These are preliminary durability observations, not a guarantee of lasting benefit.
Safety and tolerability in the case series
All 32 patients completed the 20-session treatment day.
No seizures, emergent mania or hypomania, or other serious adverse events were reported during treatment or the six-week safety follow-up in this small case series. This does not mean TMS is risk-free.
The most common treatment-related issue was discomfort. Mean scalp discomfort was approximately 5.8 on a 10-point scale. Transient headache or jaw discomfort was also reported.
INTERPRETING THE EVIDENCE
WHAT THIS STUDY ADDS
01 Practical feasibility of completing 20 TMS sessions in a single treatment day.
02 Real-world symptom observations from 32 adults with major depression.
03 Symptom follow-up through approximately six months and initial safety and tolerability observations.
04 A signal that improvement may continue over several weeks after treatment.
WHAT REMAINS UNCERTAIN
01 No sham or placebo control, no blinding, and a small sample.
02 Thirteen of 32 participants had previously responded to TMS.
03 Pharmacologic augmentation was used. The separate contributions of TMS, D-cycloserine, and lisdexamfetamine cannot be determined.
04 Results may not generalize to more severe or acute populations.
05 Long-term durability and optimal retreatment remain uncertain. Randomized controlled replication is needed.
The published regimen was not TMS alone.
The published single-day regimen included single-dose D-cycloserine 125 mg and lisdexamfetamine 20 mg before treatment as pharmacologic augmentation. These uses for TMS augmentation were off-label. The study cannot determine how much of the observed outcome was attributable to TMS, either medication, or their combination.
SOURCE & STUDY DISCLOSURES
Vaughn DA, Marino B, Engelbertson A, et al. Real-world effectiveness of a single-day regimen for transcranial magnetic stimulation using Optimized, Neuroplasticity-Enhanced techniques in Depression (ONE-D): An open-label case series. Transcranial Magnetic Stimulation. 2025;5:100200. doi:10.1016/j.transm.2025.100200
Several study authors disclosed employment, board, equity, consulting, patent, or other relationships with Ampa Health and other TMS-related organizations. Readers should consider these published disclosures alongside the observational study design. This is not an allegation of misconduct.
WHAT WE KNOW
WHAT REMAINS UNCERTAIN
PRIVATE CARE, DESIGNED AROUND LOCATION

YOUR PHYSICIAN
Christian S. Monsalve, M.D.
CLINICAL CONTENT REVIEWED BY
Christian S. Monsalve, M.D.
Board-Certified Psychiatrist · Founder & Medical Director, Verigrate Health
Last reviewed: September 2026
PRIVATE-PAY CARE
QUESTIONS
ONE-DAY TMS · VERIGRATE HEALTH